Black Death Interactive / Pathogen Profile / What did it do?
Bubonic Plague
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There were three forms of the disease spread by the bacterium Yersinia pestis. The most common of these, and the one responsible for so much death and loss during the 14th century, was the bubonic plague.

This takes its name from the primary symptom: the patient will develop painful and swollen lymph nodes, which are called buboes. The bacteria that enter the body from the infected flea bite, and typically the closest lymph nodes will become the point from which the bacteria begin to multiply. These nodes often developed in a patient’s groin, neck, or armpits. If a physician or barber surgeon attempted to open these buboes, they would ooze pus and bleed heavily.

"In men and women alike it first betrayed itself by the emergence of certain tumours in the groin or armpits, some of which grew as large as a common apple, others as an egg…" G. Boccaccio, Decameron.

After this, someone suffering from the plague could be expected to endure an acute fever, reaching temperatures as high as 41°C (around 106 °F). This would be accompanied by diarrhoea and vomiting (victims can even begin to vomit blood). In some instances, the patient would also develop bizarre spots and rashes, usually black in colour, which discoloured the body. This usually affected the extremities, such as the fingers and toes. Without the correct treatment, around 80% of patients that contract bubonic plague will be dead within 8 days.

As well as being spread by the bites of infected fleas, Yersinia pestis could also be spread by person-to-person contact. When an infected person coughed, sneezed, or spread infected air droplets by some other way, then they could infect those nearby with either pneumonic or septicaemic plague. Some of the symptoms were the same for these forms of the disease, but they were more virulent and much more frightening. To contract either was, in almost every circumstance, a death sentence.

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Black Death Interactive / Pathogen Profile / What did it do?
Pneumonic Plague
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Some academics argue that once the plague had arrived in Europe via the rats carrying the infected fleas, the bubonic plague gave way rapidly to the pneumonic. This would have allowed the disease to spread over land much more quickly. This would also explain the lethality of the plague in medieval Eurasia: pneumonic plague has a mortality rate of up to 95% if a patient is not treated correctly.

In its pneumonic form, the disease would form quickly, usually over the course of just 1 to 3 days (compared to up to a week for the bubonic). The sufferer would endure a high fever, headaches and weakness, compounded by the rapid onset of severe respiratory problems. Pneumonia would set in, characterised by shortness of breath and a wracking, debilitating cough. Respiratory failure at this point was highly common, accompanied by bloody and free-flowing sputum from the patient.

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Septicaemic Plague
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The septicaemic plague is fortunately the least common of the three forms of the plague, because the mortality rate for this illness is close to 100%. It is an infection of the blood that can present itself in a horrible array of symptoms, including:

• Gastrointestinal distress, such as nausea, vomiting and diarrhoea (both with blood).

• Fever and chills

• Organ failure

• Shock

• Respiratory difficulties

• Bleeding under the skin due to the inability of blood to clot. In turn, this would result in the patient’s skin being covered in purple blotches (purpura).

• Tissue would begin to die, meaning that a patient’s extremities (fingers and toes, etc) would turn black, rot, and may fall off.

The sliver of comfort one could take is that this form of the virus was so lethal that it was not uncommon for the patient to mercifully pass away before being afflicted by all of these symptoms…

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Black Death Interactive / Pathogen Profile / What did it do?
Bubonic Plague
Groin / armpit

"For both men and women, it began with swellings either in the groin or under the arms." Boccaccio’s account of the plague noted the emergence of these swellings – buboes – as one of the tell-tale symptoms of the disease. They varied in size, and when cut it into they would often leak pus and blood. These buboes – from where the plague gained its name – often developed in the lymph nodes closest to the site of the initial bite from the infected flea.

DID YOU KNOW: The fourteenth century Italians referred to the buboes as ‘gavoccioli’.

Groin / armpit
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Pneumonic Plague
Mouth / throat

The most obvious symptom of the pneumonic plague was, unsurprisingly, coughing. Specifically, however, patients suffered from hemoptysis. This means coughing up blood, and it is a sign of bleeding in the airways (such as the larynx, the trachea, or the lungs).

Mouth / throat
Black Death Interactive / Pathogen Profile / What did it do?
Septicaemic Plague
Heart

As the bacteria begin to multiply in the bloodstream, the patient begins to suffer from Disseminated Intravascular Coagulation (DIC). This means that tiny blood clots being to form throughout the body. The result is localised necrosis, where skin begins to turn black and rot as a result of the lack of circulation.

Heart
Black Death Interactive / Pathogen Profile / What did it do?
Bubonic Plague
Head

The swellings would be followed by more common symptoms of sickness. The patient would develop splitting headaches, along with fevers and chills.

Head
Black Death Interactive / Pathogen Profile / What did it do?
Pneumonic Plague
Head

Much as with bubonic plague, a victim of pneumonic plague would also be afflicted by a high fever and chills, as well as terrible headaches.

Head
Black Death Interactive / Pathogen Profile / What did it do?
Septicaemic Plague
SKIN

The DIC also affects the body’s ability to clot blood. Bleeding becomes uncontrollable, and as blood begins to seep into the patient’s skin and other organs, they would be afflicted by visceral red and black patchy rashes across their body.

SKIN
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Bubonic Plague
Stomach

As the disease took hold, its effects began to worsen. Patients suffered from terrible gastrointestinal distress, and they would begin to endure bouts of diarrhea and vomiting as their body weakened.

Worse still, for the people desperately trying to care for them, these symptoms only helped to spread the pathogen…

Stomach
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Pneumonic Plague
Lungs / chest

The principal symptom of pneumonic plague is the rapid onset of pneumonia. Pneumonia is a severe inflammatory condition of the lungs which affects the alveoli (the small air sacks in these vital organs). Over the course of a very short time frame – perhaps as little as two to four days, the patient would be wracked by severe chest pains and shortness of breath, as well as the continuing presence of bloody mucus. More often than not for the sufferers in the 14th century, the pneumonic plague led to rapid respiratory failure and death…

Lungs / chest
Black Death Interactive / Pathogen Profile / What did it do?
Septicaemic Plague
Mouth / nose

Unable to control the internal bleeding, the patient would begin to suffer from vomiting or coughing up blood. As well as this, the patient may find that blood would begin to pour from other orifices, including the mouth, the nose, and the rectum.

The coughing could help spread the disease even further…

Mouth / nose
Black Death Interactive / Pathogen Profile / What did it do?
Bubonic Plague
Fingers / nose

Some patients were also stricken by an additional, horrible symptom, now known as Acral necrosis. This is the dark discoloration of the skin – usually on a patient’s extremities, such as fingers, toes, and noses – that was a sign of the flow of blood being disrupted for an extended period of time. In short, the skin was beginning to rot… Left untreated, necrosis can be fatal.

At a second stage, the infection began to change its character and show itself as black or livid rashes… a clear sign of death being imminent” – Boccaccio’s account also recognised the severity of necrosis as a symptom.

Fingers / nose